Improved Ventricular Function during Inhalation of PGI
نویسندگان
چکیده
Inhaled prostacyclin (PGI 2 ) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular (RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility. We investigated the effects of the inhaled PGI 2 analogs epoprostenol (EPO) and iloprost (ILO) on RV function and myocardial contractility in 9 anesthetized pigs receiving aerosolized EPO (25 and 50 ng kg –1 min –1 ) and, consecutively, ILO (60 ng kg –1 min –1 ) for 20 min each. We measured pulmonary artery pressure (PAP), RV ejection fraction (RVEF) and RV end-diastolic-volume (RV-EDV), and left ventricular end-systolic pressure-volume-relation (end-systolic elastance, E es ). EPO and ILO reduced PAP, increased RVEF and reduced RVEDV. E es was enhanced during all doses tested, which reached statistical signifi cance during EPO 25ng and ILO, but not during EPO 50ng . PGI 2 aerosol enhances myocardial contractility in healthy pigs, contributing to improve RV
منابع مشابه
Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility.
Inhaled prostacyclin (PGI(2)) aerosol induces selective pulmonary vasodilation. Further, it improves right ventricular (RV) function, which may largely rely on pulmonary vasodilation, but also on enhanced myocardial contractility. We investigated the effects of the inhaled PGI(2) analogs epoprostenol (EPO) and iloprost (ILO) on RV function and myocardial contractility in 9 anesthetized pigs rec...
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